I attempted to google my question in a few ways but with little success.
For example, enkulu, elikhulu, esikhulu, omkhulu, amakhulu and ezinkulu all mean big. When it's the difference between singular and plural, I can still see that there is a pattern like with "indlulamithi enkulu" and "izindlulamithi ezinkulu". Or that the prefixes of adjectives tend to match the noun, like with "isilwane esikhulu". However, I don't really know how to use it and if these are at all exchangeable.
On that note, since I chose the word "big" as an example, is there a reason that in some words the main part of the word is "-kulu" and in others "-khulu"?